Serum Lipid Levels, Body Mass Index, and Their Role in Coronary Artery Calcification: A Polygenic Analysis Running title: van Setten et al.; Polygenic analysis of coronary calcification
نویسندگان
چکیده
Department of Medical Genetics, Center for Molecular Medicine, Image Sciences Institute, Department of Cardiology, Department of Radiology, Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; Institute for Medical Informatics, Biometry and Epidemiology, Clinic of Cardiology, West-German Heart Centre, University Hospital Essen, Essen, Germany; Department of Genetics, Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands; Institute of Human Genetics, Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany; Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland; Department of Radiology-Radiodiagnostics, University Medical Center Groningen, University of Groningen, Groningen; Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands *contributed equally
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Serum lipid levels, body mass index, and their role in coronary artery calcification: a polygenic analysis.
BACKGROUND Coronary artery calcification (CAC) is widely regarded as a cumulative lifetime measure of atherosclerosis, but it remains unclear what is the relationship between calcification and traditional risk factors for coronary artery disease (CAD) and myocardial infarction (MI). This study characterizes the genetic architecture of CAC by evaluating the overall impact of common alleles assoc...
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